C5A ENHANCES DYSREGULATED INFLAMMATORY AND ANGIOGENIC RESPONSES TO MALARIA IN VITRO: POTENTIAL IMPLICATIONS FOR PLACENTAL MALARIA.

C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.

Placental malaria (PM) is a leading cause of maternal and infant mortality.Although the accumulation of parasitized erythrocytes (PEs) and monocytes within the placenta is thought to contribute to the pathophysiology of PM, the molecular mechanisms underlying PM remain unclear.Based on the hypothesis that excessive complement activation may contrib

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Insights Into Mechanisms of Biofilm Formation in Acinetobacter baumannii and Implications for Uropathogenesis

Multidrug resistant Acinetobacter baumannii is a serious healthcare threat.In fact, the Center for Disease Control recently reported that carbapenem-resistant A.baumannii is responsible for more than 8,500 infections, 700 deaths, and $281 million in healthcare costs annually in the United States with few, if any, treatment options available, leadin

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Exploring Spatial Patterns of Tropical Peatland Subsidence in Selangor, Malaysia Using the APSIS-DInSAR Technique

Tropical peatlands in Southeast Asia have experienced widespread subsidence due to forest clearance and drainage for agriculture, oil palm and pulp wood production, causing concerns about their function as a long-term carbon store.Peatland drainage leads to subsidence (lowering of peatland surface), an indicator of degraded peatlands, while Other F

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Basic mechanisms of platelet receptor shedding

Proteolytic shedding of the extracellular ectodomain of platelet receptors provides a key mechanism for irreversible loss of ligand-binding capacity, and for regulating platelet function in health and disease.Platelets derived from megakaryocytes are small anucleate cells in peripheral blood, with the ability to rapidly adhere, become activated, an

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